John Roach
National Geographic News
February 15, 2005
Scientists have shown that, for hepetitis B vaccine, genetically modified potatoes may be an alternative to the syringe and needle.
The hepatitis B virus (HBV) causes liver failure and liver cancer. Despite the availability of a safe, injectable vaccine, the virus currently infects an estimated 350 million people worldwide and kills about a million people every year.
In recent years scientists have raced to develop oral vaccines with genetically modified plants as a means to overcome the economic and safety limitations of syringe-and-needle vaccination programs, especially in developing countries.
“The whole concept of oral vaccines, versus injections, is a very attractive one. As you can imagine, we are used to taking things by mouth. They are easy, and there are not associated problems with potential contamination due to syringes and needles,” said Yasmin Thanavala, an immunologist at the Roswell Park Cancer Institute in Buffalo, New York.
Previously researchers have shown that potatoes can deliver vaccines for intestinal pathogens such as the E. coli and Norwalk viruses, which enter the body via the mouth.
This week in the research journal Proceedings of the National Academy of Sciences, Thanavala and colleagues report on the first human, or clinical, trial for a plant-derived HBV vaccine. HBV is transmitted by blood or sexual fluids.
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